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-->Introduction

-->Materials and Methods

-->Results

• Performance

• M. hyo-like lesions at slaughterhouse

• A.p-like lesions at slaughterhouse

-->Conclusions

 

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EFFICACY OF COGLAPIX^® AND HYOGEN^® VACCINES IN THE PREVENTION OF PLEUROPNEUMONIA AND ENZOOTIC PNEUMONIA

By Krejci R.¹, Merialdi G.², Luppi A.², Saldivar D.³, Lopez A.¹

¹Ceva, Libourne, France, ²IZSLER Italy, ³Ceva Mexico

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Introduction

Porcine pleuropneumonia induced by Actinobacillus pleuropneumoniae (A.p) and enzootic pneumonia due to primarily Mycoplasma hyopneumoniae (M. hyo)belong to most important and widely spread diseases of pigs. Their control by preventive vaccination was proven in many studies.

Although A.p is a primary pathogen which doesn’t require previous triggering to produce the disease, M. hyo can increase the severity of A.p infection. Vaccination against both pathogens is thus advisable in farms affected by those agents.

The aim of this study was to compare the efficacy of Coglapix^® - A.p toxoid vaccine (Ceva) and Hyogen^® - M. hyo vaccine (Ceva) with competitor vaccines in the farm with the history of enzootic disease caused by A.p and M. hyo.

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Materials and Methods

Weaned piglets were divided into two groups (G1 and G2):

- G1: 206 piglets were vaccinated with Hyogen^® (M. hyo vaccine) at 3 weeks of age (W), and with Coglapix^® (A.p toxoid vaccine) at 12 and 15W.

- G2: 207 piglets were vaccinated with competitor M. hyo and toxoid A.p products using the same program as G1.

Both groups were vaccinated against PRRSv at 2W and PCV2 at 3W.

Mortality, average daily gain (ADG) and feed conversion rate (FCR) were measured in the fattening period. Ceva Lung Program - Scoring Methodology was used to score lung lesions at the slaughterhouse. In particular, a modified Madec¹ method was used for evaluating enzootic pneumonia (EP)-like lesions and the SPES² method for scoring pleurisy. SPES method has 5 different score (0: no lesions; 1: ventro-cranial pleurisy; 2, 3 and 4: dorso-caudal pleurisy of increasing level of severity). Dorso-caudal pleural lesions are considered suggestive of recovered pleuropneumonia³.

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Results

1. Performance:

G1 group had lower mortality and FCR than G2 and higher ADG for 43g (Table 1). The difference in ADG was statistically significant in favour of G1 (*p<0.05).

Table 1 Comparison of performance indicatiors

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2. M. hyo-like lesions at slaughterhouse:

Pigs of G1 had lower incidence (*p<0.05) of lungs with broncho-pneumonia (BP lungs) with lower % of affected parenchyma in BP lungs (Figure 1).

Figure 1 Broncho-pneumonic lesion (M. hyo like)

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3. A.p-like lesions at slaughterhouse

Pigs belonging to G1 showed lower prevalence and severity of dorso-caudal pleurisy than G2, as described inFigure 2.

Figure 2 Dorso-caudal pleurisy lesions

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Conclusions

In the present study, Hyogen^® and Coglapix^® conferred higher protection against EP and pleuropneumonia than competitor vaccines. Lung scoring results in slaughter pigs reflect the relation between the level of protection of lungs and most common indicators of performance. For this reason, it can be considered a relevant diagnostic tool in assessing the efficiency of vaccines against those respiratory pathogens.

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References

Madec F. et al., 1982,J Rec Porc Fr,14, 405-412

Dottori M. et al., 2007,Large Anim Rev, 161-165

Gottschal M., 2012, Disease of Swine, 10^th Edition

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(Source: Axis Issue 02 / Sept 2013 - Ceva Asia Pacific - Proceedings APVS 2013)

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