Benefits Beyond Protection





--> Introduction

--> CEVAC® CORYMUNE 4K & 7K: Benefits Beyond Protection

--> Conclusion





By Dr Marcelo PANIAGO - Regional Market Manager – Poultry, Ceva Animal Health Asia Pacific



Preventing losses due to common diseases such as Infectious Coryza (IC), Newcastle Disease (ND), Egg Drop Syndrome (EDS) and Infectious Bronchitis (IB) has been a constant challenge for the poultry industry. More recently, concerns related to Salmonella Enteritidis (SE*) have increased worldwide and its prevention has become a major issue for egg producers and breeder farmers.

Basically, biosecurity and vaccination are the tools used for the prevention of all these aforementioned diseases. However, most of the vaccines are applied separately and therefore extra handlings of the pullets are necessary. Consequently, it increases the cost of vaccination, builds up the stress and, more importantly, it can affect the growth of the pullets which will negatively impact the flock performance. For these reasons, the modern poultry industry requires more convenient solutions against these diseases.

* SE = Salmonella enterica subspecie enterica serovar Enteritidis

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Ceva Santé Animale developed a unique and innovative combination of vaccines to prevent all these major diseases which cause economic losses to the egg industry: CEVAC® CORYMUNE 4K and CEVAC® CORYMUNE 7K.


CEVAC® CORYMUNE 4K is an inactivated vaccine which contains the serotypes A, B and C of Avibacterium paragallinarum (formerly known as Haemophilus paragallinarum) and Salmonella Enteritidis (SE) in aluminum hydroxide adjuvant and it is used for prime vaccination.

CEVAC® CORYMUNE 7K is also an inactivated vaccine containing the serotypes A, B and C of Avibacterium paragallinarum, SE, ND, IB and EDS in oily adjuvant and it is used for booster vaccination.

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Trial 1

Commercial layer type pullets were vaccinated with CEVAC® CORYMUNE 4K at 12 weeks and revaccinated with CEVAC® CORYMUNE 7K at 16 weeks of age. Three weeks after this booster vaccination (19 weeks of age), the chickens were challenged with serotypes A, B and C of Avibacterium paragallinarum and observed during one week for clinical signs of the disease.

The results are presented in the Graphic 1.

Graphic 1 Protection Against A, B & C of Avibacterium paragallinarum Challenges


These results show a very high level of protection induced by the combination of CEVAC® CORYMUNE 4K and CEVAC® CORYMUNE® 7K against challenges of three serotypes of Avibacterium paragallinarum.

At 16 and 20 weeks of age, serology (Haemagglutination Inhibition) for ND, IB, EDS was carried out. In the same way, at 12, 16 and 20 weeks of age, a serological test (Microagglutination) for SE was performed.

The results are expressed in Graphic 2, 3, 4 & 5.

Graphic 2 Antibody Response Against Newcastle Disease


Graphic 3 Antibody Response Against Infectious Bronchitis


Graphic 4 Antibody Response Against Egg Drop Syndrome


Graphic 5 Antibody Response Against Salmonella Enteritidis


All these serological results show a consistent and high seroconversion against NDV, IBV, EDS and SE which correlates with protection against these diseases.

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Trial 2

A very comprehensive trial was carried out in an independent laboratory in Brazil (FCAV-UNESP – State University of São Paulo, School of Agricultural and Veterinary Sciences Jaboticabal Campus, Department of Veterinary Pathology Avian Pathology Laboratory) in order to assess the efficacy of the combination of CEVAC® CORYMUNE 4K and CEVAC® CORYMUNE 7K against a heavy challenge of Salmonella Enteritidis.

In this experiment, commercial layer type pullets were vaccinated with CEVAC® CORYMUNE 4K at 5 weeks and revaccinated with CEVAC® CORYMUNE 7K at 9 weeks of age. Three weeks after this booster vaccination (12 weeks of age), the chickens were challenged with approximately 1.2 x 108-9 CFU/ml SENalrSpcr (Salmonella Enteritidis strain resistant to nalidixic acid and spectinomycin) by oral route (2 ml). The chickens were monitored for 3 weeks and cloacal swabs were taken at 3, 6, 10, 13, 17 and 20 days post challenge (dpc).

These results, expressed in the Graphic 6, undoubtedly show that pullets vaccinated with CEVAC® CORYMUNE 4K and CEVAC® CORYMUNE 7K had a significant decrease of SE in the faecal contents. Consequently, it indicates a substantial reduction on environmental contamination by these bacteria.

Graphic 6 Cumulative Amount of Birds SE Positive on Cloacal Swabs at Different Days Post Challenge


Numbers with different letters in the same dpc are statistically different (p<0.05)

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Even though the use of vaccines is compulsory in protecting chickens against undesirable diseases, the vaccination procedure is always stressful for the flock. Moreover, any unnecessary handling of the chickens can have negative impact on their productive performance.

The modern poultry industry has long adopted multivalent inactivated vaccines as a way to overcome this problem. CEVAC® CORYMUNE 4K and CEVAC® CORYMUNE 7K is the most innovative and convenient combination in preventing the usual problems that have challenged poultry producers all over the world.

Results of several trials show that this combination induces high levels of protection against the 3 serotypes (A, B and C) of Avibacterium paragallinarum. It also reduces significantly the colonisation of the internal organs by SE and consequently its shedding to the environment. Furthermore, it protects against ND, IB and EDS challenges.

For all of these aforementioned reasons, CEVAC® CORYMUNE 4K plus CEVAC® CORYMUNE 7K is a unique combination that provides benefits beyond protection.

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